I'm not sure, since the brain's structures and function are interrelated, and the brain is the primary intermediary of conscious self-experience. Meaning if one experiences themselves as a masculine/male person, the brain is likely to reflect that.

Here's a video of Robert Sapolsky explaining his understanding of gender in the human brain. The timestamp (919 seconds, about 1/3 of the way through) marks where he states a more complete summary of what I just said.